Article

The nuclear RNAi factor, NRDE2, prevents the accumulation of DNA damage during mitosis in stressful growth conditions

2018-09-27

Abstract excerpt

Organisms have evolved multiple mechanisms to prevent and repair DNA damage to protect the integrity of the genome, particularly under stressful conditions. Unrepaired DNA damage leads to genomic instability, aneuploidy, and an increased risk for cancer. Before the cell can divide, it must repair damaged DNA and it is thought that this process requires global silencing of most transcription. In C. elegans , NRDE-...

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Literature Corpus work: 625e36d7-02ef-5ebb-81a6-2aa5b4d9bf45
DOI: 10.1101/428250

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