Article

Cofilin-1 is a Redox-Sensitive Guard of the NLRP3 Inflammasome

2025-05-23

Abstract excerpt

<title>Abstract</title> <p> Mutations in NLRP3 cause a spectrum of autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS). Reactive oxygen species (ROS) play a key role in NLRP3 inflammasome activation. We identified cofilin-1, an actin-severing protein, as a negative regulator of the NLRP3 inflammasome. In resting cells, cofilin-1 directly bound NLRP3, but upon stimulation with NLRP3 inflammas...

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Literature Corpus work: 9ba6def4-8f58-5579-9c9f-39235f8bb837
DOI: 10.21203/rs.3.rs-6648864/v1

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