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Article

Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome.

Nature immunology - 1 May 2026

Park Yong Hwan, Batu Ezgi D, Matthiasardottir Brynja, Kim YeJi, Akkaya-Ulum Yeliz Z, Kastner Daniel L, Chae Jae Jin

Abstract excerpt

Mutations in NLRP3 can cause a spectrum of the autoinflammatory cryopyrin-associated periodic syndromes (CAPS). Reactive oxygen species (ROS) have a central role in NLRP3 inflammasome activation. Here we show that cofilin-1, an actin-severing protein, is a negative regulator of the NLRP3 inflammasome. In resting cells, cofilin-1 directly bound NLRP3, but after stimulation with NLRP3 inflammasome activators, it...

Read the complete abstract on PubMed

Topics

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Share to Carrier Proteins
Share to Cryopyrin-Associated Periodic Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Inflammasomes

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Oxidation-Reduction

Share to Protein Binding

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 41851524
DOI: 10.1038/s41590-026-02477-8
PMCID: PMC13051731

Genes

NLRP3
CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome.PMID 41851524Read ↗

Cofilin-1 is a Redox-Sensitive Guard of the NLRP3 InflammasomeSemantic proximity Read ↗

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