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Article

The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity

25 Dec 2023

Abstract excerpt

From studies of individual families to global collaborative efforts, the NLRP3 inflammasome is now recognized to be a key regulator of innate immunity. Activated by a panoply of pathogen-associated and endogenous triggers, NLRP3 serves as an intracellular sensor that drives carefully coordinated assembly of the inflammasome, and downstream inflammation mediated by IL-1 and IL-18. Initially discovered as the cause...

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PMID: 38146057
DOI: 10.1111/imr.13292

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