Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.

Immunity - 1 Mar 2004

Agostini Laetitia, Martinon Fabio, Burns Kimberly, McDermott Michael F, Hawkins Philip N, Tschopp Jürg

Abstract excerpt

Mutations within the NALP3/cryopyrin/CIAS1 gene are responsible for three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and CINCA. The NALP3 protein is homologous to NALP1, which is a component of the inflammasome, a molecular platform that activates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to CARD Signaling Adaptor Proteins
Share to Caspase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Interleukin-1

Share to Macromolecular Substances

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Protein Precursors

Source

Identifiers

PMID: 15030775
DOI: 10.1016/s1074-7613(04)00046-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15030775-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.PMID 15030775Read ↗

NALP3: a key player in caspase-1 activation.Semantic proximity Read ↗

[Pathophysiological mechanisms underlying cryopyrin-associated periodic syndromes: genetic and molecular basis and the inflammasome].Semantic proximity Read ↗

"Mutation negative" familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies.Semantic proximity Read ↗

The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunitySemantic proximity Read ↗

A clinical update on inflammasomopathies.Semantic proximity Read ↗

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU.Semantic proximity Read ↗

Cryopyrin-associated periodic syndromes and autoinflammation.Semantic proximity Read ↗

CAPS--pathogenesis, presentation and treatment of an autoinflammatory disease.Semantic proximity Read ↗

Current status of understanding the pathogenesis and management of patients with NOMID/CINCA.Semantic proximity Read ↗

Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionSemantic proximity Read ↗

Identification of a variant in NLRP3 gene in a patient with Muckle-Wells syndrome: a case report and review of literature.Semantic proximity Read ↗

[CAPS: cryopyrin-associated periodic syndrome].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.