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Article

The intrinsic amyloidogenic propensity of cofilin-1 is aggravated by Cys-80 oxidation: A possible link with neurodegenerative diseases.

Biochemical and biophysical research communications - 10 Sept 2021

Kaushik Vibha, Brünnert Daniela, Hanschmann Eva-Maria, Sharma Phulwanti Kumari, Anand Bibin G, Kar Karunakar, Kateriya Suneel, Goyal Pankaj

Abstract excerpt

Cofilin-1, an actin dynamizing protein, forms actin-cofilin rods, which is one of the major events that exacerbates the pathophysiology of amyloidogenic diseases. Cysteine oxidation in cofilin-1 under oxidative stress plays a crucial role in the formation of these rods. Others and we have reported that cofilin-1 possesses a self-oligomerization property in vitro and in vivo under physiological conditions....

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Identifiers

PMID: 34256187
DOI: 10.1016/j.bbrc.2021.07.013

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