Article
Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
EBioMedicine - 1 Oct 2016
Taudien Stefan, Lausser Ludwig, Giamarellos-Bourboulis Evangelos J, Sponholz Christoph, Schöneweck Franziska, Felder Marius, Schirra Lyn-Rouven, Schmid Florian, Gogos Charalambos, Groth Susann, Petersen Britt-Sabina, Franke Andre, Lieb Wolfgang, Huse Klaus, Zipfel Peter F, Kurzai Oliver, Moepps Barbara, Gierschik Peter, Bauer Michael, Scherag André, Kestler Hans A, Platzer Matthias
Abstract excerpt
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. For its clinical course, host genetic factors are important and rare genomic variants are suspected to contribute. We sequenced the exomes of 59 Greek and 15 German patients with bacterial sepsis divided into two groups with extremely different disease courses. Variant analysis was focusing on rare deleterious single...
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