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Article

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

The Lancet. Respiratory medicine - 1 Apr 2016

Davenport Emma E, Burnham Katie L, Radhakrishnan Jayachandran, Humburg Peter, Hutton Paula, Mills Tara C, Rautanen Anna, Gordon Anthony C, Garrard Christopher, Hill Adrian V S, Hinds Charles J, Knight Julian C

Abstract excerpt

BACKGROUND: Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We investigated this heterogeneity by defining interindividual variation in the transcriptome of patients with sepsis and related this to outcome and genetic diversity. METHODS: We assayed peripheral blood leucocyte global gene expression for a prospective discovery cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26917434
DOI: 10.1016/S2213-2600(16)00046-1
PMCID: PMC4820667

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