Article
Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.
Nature communications - 25 Feb 2026
Zhang Ping, MacLean Patrick, Jia Alicia, O'Neill Callum R, Allcock Alice, Prince Ethan, Ozcan Bora, Doll Roman M, Dyne Imogen, Cano-Gamez Kiki, Qin Hanyu, Wainwright Chloe, Scozzafava Giuseppe, Brown Andrew C, Davies James O J, Chong Amanda Y, Mentzer Alexander J, Burnham Katie L, Davenport Emma E, Knight Julian C
Abstract excerpt
Sepsis is a heterogeneous clinical syndrome with a high mortality, requiring personalised stratification strategies. Here, we characterise genetic variation that modulates MTOR, a critical regulator of metabolism and immune responses in sepsis. The effects are context specific, involving a regulatory element that affects MTOR expression in activated T cells with opposite effect in neutrophils. We show that the...
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