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Article

Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep.

JAMA neurology - 1 Dec 2013

Lim Andrew S P, Yu Lei, Kowgier Matthew, Schneider Julie A, Buchman Aron S, Bennett David A

Abstract excerpt

IMPORTANCE: The apolipoprotein E (APOE [GenBank, 348; OMIM, 107741]) ε4 allele is a common and well-established genetic risk factor for Alzheimer disease (AD). Sleep consolidation is also associated with AD risk, and previous work suggests that APOE genotype and sleep may interact to influence cognitive function. OBJECTIVE: To determine whether better sleep consolidation attenuates the relationship of the APOE...

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Source

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Identifiers

PMID: 24145819
DOI: 10.1001/jamaneurol.2013.4215
PMCID: PMC3859706

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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