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TGFBR1 tagging SNPs and gastric cancer susceptibility: a two-stage case-control study in Chinese population.

Molecular carcinogenesis - 1 Feb 2014

Chen Jianjian, Miao Lin, Jin Guangfu, Ren Chuanli, Ke Qiao, Qian Yun, Dong Meihua, Li Huizhang, Zhang Qin, Ding Yanbing, Yan Zhigang, Wang Jianming, Liu Zheng, Hu Zhibin, Xu Yaochu, Ji Guozhong, Shen Hongbing

Abstract excerpt

The transforming growth factor (TGF)-β is a potent growth inhibitor primarily responsible for cell growth, differentiation, and apoptosis, and frequently perturbed during development of tumors, including gastric cancer. TGF-β receptor type I (TGFβR1) may be a modifier of cancer risk by constitutively decreasing the TGF-β inhibitory signals during early tumorigenesis and increasing the TGF-β signals in tumor...

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Identifiers

PMID: 22911926
DOI: 10.1002/mc.21954

Genes

TGFBR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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