Molecular insights into TGF-B signalling pathway disruption by non-synonymous SNPs variants in COPD: an in silico and molecular dynamics simulation study.

Abstract excerpt

Transforming Growth Factor Beta (TGF-B) signalling plays a central role in maintaining vascular homeostasis, regulating extracellular matrix production, and controlling pulmonary vascular remodelling. Disruption of this pathway has been closely associated with pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD). Genetic variations, particularly non-synonymous single-nucleotide...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Molecular Docking Simulation
• Share to Molecular Dynamics Simulation