Article
Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.
Journal of neurology - 1 Jul 2007
Goris A, Williams-Gray C H, Foltynie T, Brown J, Maranian M, Walton A, Compston D A S, Barker R A, Sawcer S J
Abstract excerpt
Given the known roles of TGFbeta2 in both regulating the immune system and promoting the survival of dopaminergic neurons, it is feasible that genetic variations in TGFB2 might play an aetiological role in neurological diseases such as Multiple Sclerosis (MS) and Parkinson's disease (PD). Hence we performed an indirect association analysis of TGFB2 using 8 haplotype-tagging SNPs in a population of 937 MS...
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