Article

Quantitative characterization of CTLA4 trafficking and turnover using a combined <i>in vitro</i> and <i>in silico</i> approach

2017-02-08

Abstract excerpt

CTLA4 is an essential negative regulator of T cell immune responses and is a key checkpoint regulating autoimmunity and anti-tumour immunity. Genetic mutations resulting in a quantitative defect in CTLA4 are associated with the development of an immune dysregulation syndrome. Endocytosis of CTLA4 is rapid and continuous with subsequent degradation or recycling. CTLA4 has two natural ligands, the surface transmembr...

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Literature Corpus work: 9b70ad24-4d5a-5eae-a21a-0316e5c04993
DOI: 10.1101/106898

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