Article
CD1a and MHC class I follow a similar endocytic recycling pathway.
Traffic (Copenhagen, Denmark) - 1 Sept 2008
Barral Duarte C, Cavallari Marco, McCormick Peter J, Garg Salil, Magee Anthony I, Bonifacino Juan S, De Libero Gennaro, Brenner Michael B
Abstract excerpt
CD1 proteins are a family of major histocompatibility complex (MHC) class I-like antigen-presenting molecules that present lipids to T cells. The cytoplasmic tails (CTs) of all human CD1 isoforms, with the exception of CD1a, contain tyrosine-based sorting motifs, responsible for the internalization of proteins by the clathrin-mediated pathway. The role of the CD1a CT, which does not possess any sorting motifs, as...
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