Article

CD96-mediated internalisation of ligand CD155 as a novel mechanism for immune regulation

2026-06-02

Abstract excerpt

CD96 is a member of the immunoglobulin superfamily including TIGIT and CD226 that bind to a shared ligand, CD155. This family of co-receptors and its ligands are dysregulated in various autoimmune conditions and cancers, highlighting therapeutic potential. While TIGIT and CD226 are recognised co-inhibitory and co-stimulatory receptors respectively, the function of CD96 remains incompletely defined. Here, we assess...

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Literature Corpus work: 3cd6dda5-d2f8-593b-ab7c-a1fa26664281
DOI: 10.64898/2026.05.29.727853

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