Article

Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies

2024-04-16

Abstract excerpt

Past studies have demonstrated higher clearance for monoclonal antibodies possessing increased rates of non-specific endocytosis. However, this metric is oftentimes evaluated indirectly using biophysical techniques or cell surface binding studies that may not provide insight into the specific rates of cellular turnover. Furthermore, few examples evaluating non-specific endocytosis have been reported for a therapeu...

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Literature Corpus work: 802fdb1b-7c38-56ce-82ff-034eaf5bd015
DOI: 10.1101/2024.04.16.589824

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