PD-1 endocytosis unleashes the cytolytic potential of checkpoint blockade in tumor immunity

Abstract excerpt

PD-1 immune checkpoint blockade (ICB) is a key cancer treatment. While blocking PD-1 binding to ligand is known, the role of internalization in enhancing ICB efficacy is less explored. Our study reveals that PD-1 internalization helps unlock ICB's full potential in cancer immunotherapy. Anti-PD-1 induces 50%–60% surface PD-1 internalization from human and mouse cells, leaving low to intermediate levels of...

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