Article

Exaggerated NMDA Receptor–Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout Mice

2025-08-27

Abstract excerpt

Fragile X syndrome (FXS), the most common monogenic neurodevelopmental disorder associated with autism and intellectual disability, results from the loss of expression of the FMR1 gene. Synaptic and circuit-level abnormalities are well documented in FXS and extensively studied in the Fmr1 KO mouse model. In CA1 hippocampal neurons functional, molecular and structural synaptic changes have been described yet the...

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Literature Corpus work: 9b701fe0-a6f1-5524-b616-8bfa7092182a
DOI: 10.1101/2025.08.26.672454

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