Article

Impaired reliability and precision of spiking in adults but not juveniles in a mouse model of Fragile X Syndrome

2018-12-21

Abstract excerpt

Fragile X Syndrome (FXS) is the most common source of intellectual disability and autism. Extensive studies have been performed on the network and behavioral correlates of the syndrome but our knowledge about intrinsic conductance changes is still limited. In this study we show a differential effect of FMRP Knock Out (KO) in different sub-sections of hippocampus using whole cell patch clamp in mouse hippocampal sl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41f9abe0-04de-52a0-9a66-7f5dcf07af75
DOI: 10.1101/503714

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired reliability and precision of spiking in adults but not juveniles in a mouse model of Fragile X SyndromeDOI 10.1101/503714Read

Hypoplasticity in sensory-driven necortical circuits of Fragile X miceSemantic proximity Read

Abnormal Presynaptic Short-Term Plasticity and Information Processing in a Mouse Model of Fragile X SyndromeSemantic proximity Read

Altered A-type potassium channel function impairs dendritic spike initiation and temporammonic long-term potentiation in Fragile X syndromeSemantic proximity Read

Higher hyperpolarization activated current (I <sub>h</sub> ) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X miceSemantic proximity Read

Cellular and circuit excitability in rodent models of neurodevelopmental disordersSemantic proximity Read

Extracellular spike waveform analysis reveals cell type-specific changes in the superior colliculus of fragile X miceSemantic proximity Read

Exaggerated NMDA Receptor–Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout MiceSemantic proximity Read

Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channelsSemantic proximity Read

Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome.Semantic proximity Read

A databank for intracellular electrophysiological mapping of the adult somatosensory cortexSemantic proximity Read

α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns.Semantic proximity Read

Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in theScn1aHaploinsufficiency Mouse Model of Dravet SyndromeSemantic proximity Read