Article

Inhibition of BET Recruitment to Chromatin As An Effective Treatment for MLL-Fusion Leukaemia

2011-11-18

Abstract excerpt

Abstract Abstract 55 Recurrent chromosomal translocations involving the mixed lineage leukaemia (MLL) gene initiate aggressive forms of leukaemia, which confer a poor prognosis and are often refractory to conventional therapies. Recent efforts have begun to unravel the molecular pathogenesis of these malignancies. Several groups have demonstrated that MLL-fusions associate with two macromolecular chromatin complex...

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Literature Corpus work: 9b3b57df-5f33-533c-8dcc-1e4b2fb4e25c
DOI: 10.1182/blood.v118.21.55.55

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