Article

Integrated analysis implicates novel insights of NMB into lactate metabolism and immune response prediction in primary glioblastoma

2025-10-28

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM), the most aggressive primary brain tumor in adults, exhibits profound treatment resistance and poor prognosis. Despite advances in immunotherapy for other cancers, GBM remains refractory, potentially due to its lactate-rich, immunosuppressive tumor microenvironment (TME). While aerobic glycolysis-driven lactate accumulation is known to acidify the TME and impair immune funct...

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Literature Corpus work: 026a1e72-8324-5b88-95a3-d4e38e31466d
DOI: 10.1101/2025.10.28.685000

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