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Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment

20 Aug 2025

Abstract excerpt

Abstract Midkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into a harmonized cohort of 1,017 adult gliomas, including 256 GBM samples. We complemented this with freshly collected human GBM tissues and matched primary...

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PMID: 40835683
DOI: 10.1038/s41598-025-16253-5

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