Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration.

Human mutation - 1 Jan 2026

Li Mengtong, Liu Jiayi, Liu Zichen, Liu Xia, Lun Peng

Abstract excerpt

Glioblastoma (GBM) remains a lethal brain tumor with limited prognostic tools. Metabolic reprogramming, particularly in understudied pathways like propionate metabolism, may offer new biomarkers. Here, we identified a novel prognostic signature based on seven propionate metabolism-related genes (SLC9A1, ELANE, ACADS, SOAT2, MYD88, ADSL, and BMP2) from the TCGA-GBM cohort. A risk scoring model was constructed via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Glioblastoma

Share to Multiomics

Share to Propionates

Share to Transcriptome

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 42147808
DOI: 10.1155/humu/6998123
PMCID: PMC13179470

Genes

ACADS
ADSL
BMP2
ELANE
IDH1
MYD88
RB1
SLC9A1
SOAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration.PMID 42147808Read ↗

Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastomaSemantic proximity Read ↗

Integrated analysis implicates novel insights of NMB into lactate metabolism and immune response prediction in primary glioblastomaSemantic proximity Read ↗

Integrative multi-omics Analysis Proposes a Metabolic Classification of Gliomas: Distinct Metabolic States, Immune Infiltration, and PrognosisSemantic proximity Read ↗

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read ↗

Proteogenomic and metabolomic characterization of human glioblastoma.Semantic proximity Read ↗

Proteomic Profiling of Gliomas Unveils Immune and Metabolism-Driven Subtypes with Implications for Anti-Nucleotide Metabolism TherapySemantic proximity Read ↗

Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based ApproachSemantic proximity Read ↗

Exploration of prognosis and immune infiltration characteristics in Glioblastoma Multiforme based on Lipid Metabolism related GenesSemantic proximity Read ↗

Interplay of Sphingolipid Metabolism in Predicting Prognosis of GBM Patients: Towards Precision ImmunotherapySemantic proximity Read ↗

Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas.Semantic proximity Read ↗

Proteogenomics of glioblastoma associates molecular patterns with survivalSemantic proximity Read ↗

Development and Validation of a Propionate Metabolism-Related Gene Signature for Prognostic Prediction of Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.