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Article

Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.

PloS one - 1 Jan 2013

Bakre Abhijeet, Andersen Lauren E, Meliopoulos Victoria, Coleman Keegan, Yan Xiuzhen, Brooks Paula, Crabtree Jackelyn, Tompkins S Mark, Tripp Ralph A

Abstract excerpt

Human protein kinases (HPKs) have profound effects on cellular responses. To better understand the role of HPKs and the signaling networks that influence influenza virus replication, a small interfering RNA (siRNA) screen of 720 HPKs was performed. From the screen, 17 HPKs (NPR2, MAP3K1, DYRK3, EPHA6, TPK1, PDK2, EXOSC10, NEK8, PLK4, SGK3, NEK3, PANK4, ITPKB, CDC2L5 (CDK13), CALM2, PKN3, and HK2) were validated...

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Share to A549 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Madin Darby Canine Kidney Cells

Share to MAP Kinase Kinase Kinase 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 23805279
DOI: 10.1371/journal.pone.0066796
PMCID: PMC3689682

Genes

CDK13
NEK8
PLK4
PANK4
SGK3
CALM2
DYRK3
EPHA6
EXOSC10
ITPKB
MAPK1
NEK3
NPR2
PDK2
PKN3
TPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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