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Article

Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

17 Oct 2016

Abstract excerpt

Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host factors involved in EV71 replication in human rhabdomyosarcoma cells. Enrichment analyses reveal overrepresentation in processes like mitotic cell cycle and transcriptional regulation. We have carried out...

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PMID: 27748395
DOI: 10.1038/ncomms13150

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