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Article

The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication

25 May 2022

Abstract excerpt

In this study, we discover the tetraspanin CD81 as a host factor for the globally emerging chikungunya virus and related alphaviruses. We show that CD81 promotes replication of viral genomes in human and mouse cells, while virus entry into cells is independent of CD81. This provides novel insights into how alphaviruses hijack host proteins to complete their life cycle. Alphaviruses replicate at distinct sites of...

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Identifiers

PMID: 35612284
DOI: 10.1128/mbio.00731-22

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