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Article

Tumor mutational burden shapes success and resistance in cancer immunotherapy

2025-08-12

Abstract excerpt

Immunotherapy, particularly immune checkpoint blockade, has transformed cancer treatment, yet durable responses remain limited to a subset of patients and cancer types. Many tumors exhibit innate resistance or acquire resistance through immune evasion or neoantigen editing. A central factor in shaping these outcomes is the tumor mutational burden. However, cancer mutations can enhance or impair both cellular repli...

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Literature Corpus work
1cdb77e6-9927-5b31-b098-565a2ca93439
DOI
10.1101/2025.08.09.669487
Open publication

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Tumor mutational burden shapes success and resistance in cancer immunotherapyDOI 10.1101/2025.08.09.669487
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