Article

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective.

2023-07-26

Abstract excerpt

<title>Abstract</title> Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, and cardiac diseases. Although MERCS hav...

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Literature Corpus work: 8cb902f3-4b96-5bc2-b91d-e439a1642ad5
DOI: 10.21203/rs.3.rs-3063856/v1

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