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Article

Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

2022-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Current influenza vaccines predominantly induce immunity to the hypervariable viral hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conversely, antigenic sites on the conserved HA stem are subdominant and harbor a supersite which is targeted by broadly neutralizing antibodies (bnAbs), making it a prime target for universal vaccines. Here, we show that co-immunization of two st...

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Identifiers and source

Literature Corpus work
c2668b92-1d57-509a-87cc-a0285c84eeb6
DOI
10.1101/2022.02.11.480115
Open publication

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