Back to search

Article

O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

2023-02-22

Abstract excerpt

The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly in vivo and is mutated in subtypes of Charcot-Marie-Tooth (CMT) disease. NFs are highly dynamic, and the regulation of NF assembly state is incompletely understood. Here, we demonstrate that human NF-L is modified in a nutrient-sensitive manner by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9ae33c00-2dc3-52cd-a88d-b27005b60f5c
DOI
10.1101/2023.02.22.529563
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutationsDOI 10.1101/2023.02.22.529563
O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations.Semantic proximity
Neurofilaments and neurological disease.Semantic proximity
The O-GlcNAc cycling in neurodevelopment and associated diseases.Semantic proximity
Glycosylation of gigaxonin regulates intermediate filaments: Novel molecular insights into giant axonal neuropathySemantic proximity
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disordersSemantic proximity
O-GalNAc glycans enrich in white matter tracts and regulate nodes of RanvierSemantic proximity
The roles of dystroglycan in the nervous system: insights from animal models of muscular dystrophySemantic proximity
Neurofilamentopathy in Neurodegenerative DiseasesSemantic proximity
The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.Semantic proximity
The dazzling rise of neurofilaments: Physiological functions and roles as biomarkers.Semantic proximity
Neurofilaments: Novel findings and future challengesSemantic proximity
Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.