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Article

O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations.

Nature communications - 17 Oct 2023

Huynh Duc T, Tsolova Kalina N, Watson Abigail J, Khal Sai Kwan, Green Jordan R, Li Di, Hu Jimin, Soderblom Erik J, Chi Jen-Tsan, Evans Chantell S, Boyce Michael

Abstract excerpt

The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly in vivo and is mutated in subtypes of Charcot-Marie-Tooth (CMT) disease. NFs are highly dynamic, and the regulation of NF assembly state is incompletely understood. Here, we demonstrate that human NF-L is modified in a nutrient-sensitive manner by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37848414
DOI: 10.1038/s41467-023-42227-0
PMCID: PMC10582078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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