Article

Limited inhibition of multiple nodes in a driver network blocks metastasis

2020-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Metastasis suppression by high-dose, multi-drug targeting is largely unsuccessful due to network heterogeneity and compensatory network activation. Here we show that targeting driver network signaling capacity by limited inhibition of its core pathways is a more effective anti-metastatic strategy. This principle underlies the action of a physiological metastasis suppressor, Raf Kinase Inhibitory...

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Literature Corpus work: 9ad8c479-0bde-5462-a606-7b13642ef438
DOI: 10.1101/2020.06.05.137117

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