Article
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Lee Jiyoung, Lee Jinho, Farquhar Kevin S, Yun Jieun, Frankenberger Casey A, Bevilacqua Elena, Yeung Kam, Kim Eun-Jin, Balázsi Gábor, Rosner Marsha Rich
Abstract excerpt
The sources and consequences of nongenetic variability in metastatic progression are largely unknown. To address these questions, we characterized a transcriptional regulatory network for the metastasis suppressor Raf kinase inhibitory protein (RKIP). We previously showed that the transcription factor BACH1 is negatively regulated by RKIP and promotes breast cancer metastasis. Here we demonstrate that BACH1 acts...
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