Article
Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer.
Oncotarget - 3 Nov 2015
Perner Sven, Cronauer Marcus V, Schrader Andres Jan, Klocker Helmut, Culig Zoran, Baniahmad Aria
Abstract excerpt
Prostate Cancer (PCa) is an important age-related disease being the most common cancer malignancy and the second leading cause of cancer mortality in men in Western countries. Initially, PCa progression is androgen receptor (AR)- and androgen-dependent. Eventually advanced PCa reaches the stage of Castration-Resistant Prostate Cancer (CRPC), but remains dependent on AR, which indicates the importance of AR...
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