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Article

Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2016

Yang Yu Chi, Banuelos Carmen Adriana, Mawji Nasrin R, Wang Jun, Kato Minoru, Haile Simon, McEwan Iain J, Plymate Stephen, Sadar Marianne D

Abstract excerpt

PURPOSE: Persistent androgen receptor (AR) transcriptional activity is clinically evident in castration-resistant prostate cancer (CRPC). Therefore, AR remains as a viable therapeutic target for CRPC. All current hormonal therapies target the C-terminus ligand-binding domain (LBD) of AR. By using EPI to target AR activation function-1 (AF-1), in the N-terminal domain that is essential for AR transactivation, we...

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Identifiers

PMID: 27140928
DOI: 10.1158/1078-0432.CCR-15-2901
PMCID: PMC5010454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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