Article

Adaptive receptor expression and the emergence of disease as loss of signaling homeostasis

2026-03-22

Abstract excerpt

Our bodies have evolved to maintain homeostasis through regulatory systems that continuously adapt to keep physiological processes within a normal range. From this perspective, complex chronic disease can be understood as a breakdown of compensatory mechanisms, resulting in loss of homeostasis. Here we propose that adaptive receptor expression dynamics may serve as one such compensatory mechanism, increasing recep...

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Literature Corpus work: 9abf716a-7aca-5903-b989-59e514b9f58c
DOI: 10.64898/2026.03.21.713376

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