Article
Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty.
Mechanisms of ageing and development - 1 Nov 2008
Varadhan R, Seplaki C L, Xue Q L, Bandeen-Roche K, Fried L P
Abstract excerpt
Frailty is a state of health signified by an increased vulnerability to adverse health outcomes in the face of stressors (e.g. infection). There is emerging consensus that research on both the theory and measurement of frailty must focus on the dynamic interactions within and across systems underlying the frailty syndrome. In this paper, we propose a dynamical systems modeling approach, based on the...
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