Article
Adaptive Regenerative Error Due to Loss of Cellular Reference Pattern: A Hypothesis of Dominant Substitution in Chronic Inflammatory Microenvironments
2026-02-03
Abstract excerpt
Aberrant cellular adaptation is a hallmark of various chronic diseases, including endometriosis, metaplasia, and fibrotic conditions. This paper proposes a novel hypothesis: that such pathological transformations result from a progressive loss of the original cellular reference pattern under sustained inflammatory and dysregulated conditions. Termed the Dominant Substitution Hypothesis, this model suggests that ch...
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Identifiers and source
- Literature Corpus work
- b6b2a7a7-0342-5aba-a043-04644a3d21e1
- DOI
- 10.3897/arphapreprints.e187326