Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations.

Abstract excerpt

When cancers or bacterial infections establish, small populations of cells have to free themselves from homoeostatic regulations that prevent their expansion. Trait evolution allows these populations to evade this regulation, escape stochastic extinction and climb up the fitness landscape. In this study, we analyze this complex process and investigate the fate of a cell population that underlies the basic...

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