Article

Interference with Systemic Negative Feedback Regulation as a Potential Mechanism for Nonmonotonic Dose-Responses of Endocrine-Disrupting Chemicals

2024-09-08

Abstract excerpt

<h4>Background</h4> Endocrine-disrupting chemicals (EDCs) often exhibit nonmonotonic doseresponse (NMDR) relationships, posing significant challenges to health risk assessment and regulations. Several molecular mechanisms operating locally in cells have been proposed, including opposing actions via different receptors, mixed-ligand heterodimer formation, and receptor downregulation. Systemic negative feedback reg...

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Literature Corpus work: 4ad7c8fb-3767-5f70-b985-e5a57be417b5
DOI: 10.1101/2024.09.04.611257

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