Article

Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

2024-01-11

Abstract excerpt

Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (steatosis) during undernourishment can lead to lipotoxicity and atrophy of the liver. Here, we found that while surface populations of Astyanax mexicanus undergo this evolutionaril...

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Literature Corpus work: ded799fb-1fbe-550e-a69d-caba7234386d
DOI: 10.1101/2024.01.10.574986

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