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The Hippo Pathway in Liver Homeostasis and Pathophysiology

24 Nov 2020

Abstract excerpt

and conserved from unicellular organisms to mammals. Genetic studies of mouse and rat livers have revealed that the Hippo pathway is a key regulator of liver size, regeneration, development, metabolism, and homeostasis and that perturbations in the Hippo pathway can lead to the development of common liver diseases, such as fatty liver disease and liver cancer. In turn, pharmacological targeting of the Hippo...

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PMID: 33234023
DOI: 10.1146/annurev-pathol-030420-105050

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