Article

An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in <i>Drosophila</i>

2020-11-05

Abstract excerpt

<h4>Summary</h4> Cancer cachexia is a multifactorial syndrome associated with many types of tumors and characterized by a combination of anorexia, loss of body weight, catabolic alterations and systemic inflammation. We developed a tumor model in Drosophila larvae causing a cachexia-like syndrome, and used it to evaluate the role of steroid hormone imbalance in cachectic alterations. Cachectic larvae show reduce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16bcbb35-725e-57eb-a603-1844458a9fc4
DOI: 10.1101/2020.11.05.370411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in <i>Drosophila</i>DOI 10.1101/2020.11.05.370411Read

Cancer cachexia: lessons from DrosophilaSemantic proximity Read

Drosophila as a toolkit to tackle cancer and its metabolismSemantic proximity Read

<i>Drosophila</i> larval models of invasive tumourigenesis for in vivo studies on tumour/peripheral host tissue interactions during cancer cachexiaSemantic proximity Read

YAP disrupts bile acid homeostasis to drive cancer-associated cachexiaSemantic proximity Read

Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei SequencingSemantic proximity Read

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in <i>Drosophila</i>Semantic proximity Read

Cancer as a systemic disease : investigating tumour-host interaction in DrosophilaSemantic proximity Read

Introducing the Drosophila Melanogaster Model for Cancer ResearchSemantic proximity Read

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.Semantic proximity Read

Tumour-derived Ilp8 and Upd3 control intestinal progenitor cells depletion during cachexia in <i>Drosophila</i> larvaeSemantic proximity Read

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a <i>Drosophila</i> cachexia modelSemantic proximity Read

Integrated computational and <i>Drosophila</i> cancer model platform captures previously unappreciated chemicals perturbing a kinase networkSemantic proximity Read