Article

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

2019-04-05

Abstract excerpt

The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of isogenic viruses that carry avian- or human-derived M segments. Avian, but not human, M segments restricted viral growth and transmission in mammalian model systems, a...

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Literature Corpus work: 9a9fa0fc-279a-500d-b944-50a66ef3d839
DOI: 10.1101/599886

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