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Dysregulation of M segment gene expression contributes to influenza A virus host restriction

15 Aug 2019

Abstract excerpt

The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations.To elucidate the genetic contributions of the M segment to host adaptation, and the underlying mechanisms, we examined a panel of isogenic viruses that carry avian-or human-derived M segments.Avian, but not human, M segments restricted viral growth and transmission in mammalian model systems, and...

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PMID: 31415678
DOI: 10.1371/journal.ppat.1007892

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