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Article

The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells.

Vaccine - 4 Dec 2017

Wohlgemuth Nicholas, Ye Yang, Fenstermacher Katherine J, Liu Hsuan, Lane Andrew P, Pekosz Andrew

Abstract excerpt

The influenza A virus components of the live, attenuated influenza vaccine (LAIV) encode the HA and NA gene segments from a circulating virus strain and the remaining gene segments from the cold-adapted master donor virus, A/Ann Arbor/6/1960 (H2N2). The master donor virus imparts at least three phenotypes: temperature-sensitivity (ts), attenuation (att), and cold-adaption (ca). The genetic loci responsible for...

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Source

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Identifiers

PMID: 29079099
DOI: 10.1016/j.vaccine.2017.10.018
PMCID: PMC5696008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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