Article
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity.
Journal of virology - 15 Oct 2016
Turnbull Matthew L, Wise Helen M, Nicol Marlynne Q, Smith Nikki, Dunfee Rebecca L, Beard Philippa M, Jagger Brett W, Ligertwood Yvonne, Hardisty Gareth R, Xiao Haixia, Benton Donald J, Coburn Alice M, Paulo Joao A, Gygi Steven P, McCauley John W, Taubenberger Jeffery K, Lycett Samantha J, Weekes Michael P, Dutia Bernadette M, Digard Paul
Abstract excerpt
UNLABELLED: Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele is found in avian and mammalian viruses, but the B allele is viewed as being almost exclusively found in avian viruses. This might reflect the fact that one or both of its encoded proteins (NS1 and NEP) are maladapted for replication in mammalian hosts. To test this, a number of clade A and B avian...
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