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Article

Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.

Nature communications - 19 Jun 2018

Thompson Matthew G, Muñoz-Moreno Raquel, Bhat Prasanna, Roytenberg Renat, Lindberg John, Gazzara Matthew R, Mallory Michael J, Zhang Ke, García-Sastre Adolfo, Fontoura Beatriz M A, Lynch Kristen W

Abstract excerpt

Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP regulate IAV M segment splicing, but the mechanistic details were unknown. Here we show NS1-BP and hnRNP K bind M mRNA downstream of the M2 5' splice site (5'ss). NS1-BP binds most proximal to the 5'ss, partially overlapping...

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Share to Influenza A virus
Share to Influenza, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoprotein, U1 Small Nuclear

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Share to RNA, Viral

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Source

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Identifiers

PMID: 29921878
DOI: 10.1038/s41467-018-04779-4
PMCID: PMC6008300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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