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hnRNPM regulates influenza A virus replication through distinct mechanisms in human and avian cells: implications for cross-species transmission

28 May 2025

Abstract excerpt

The eight-segmented RNA genome of influenza A virus (IAV) is transcribed and spliced into 10 major viral mRNAs in the nucleus of infected cells. Both transcription and splicing are facilitated by the host RNA polymerase II (Pol II) machinery via interactions between the viral ribonucleoprotein (vRNP) complex and various host factors. In this study, we demonstrate that IAV vRNPs recruit species-specific...

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PMID: 40434105
DOI: 10.1128/jvi.00067-25

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